Molecular diagnostics of neurodegenerative disorders

Editorial: Molecular Diagnostics in the Detection of Neurodegenerative Disorders

Specialty section: This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Editorial on the Research Topic Molecular Diagnostics in the Detection of Neurodegenerative Disorders Neurodegenerative disorders encompass a range of medical conditions which primarily affect the neurons in the human brains. Such conditions result...

Genetic Variants in Diseases of the Extrapyramidal System

Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular genetic studies, leading to the detection of genetic mutations and loci, has co...

Materials and Metabolites of Kynureinine Pathway in Neurodegenerative Diseases and Multiple Sclerosis

Abstract Background & aim: Kynurenine pathway (KP) plays an important role in the pathogenesis of neuroinflammation and neurodegenerative disorders. In neurodegenerative diseases (NDD) such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and Multiple sclerosis (MS), brain neurons are initially involved and gradually disappear. In the present review article, the ...

New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists

Dynamic Fractal Flickering as a Tool in Research of Non-Linear Dynamics of the Evoked Activity of a Visual System and the Possible Basis for New Diagnostics and Treatment of Neurodegenerative Diseases of the Retina and Brain

This paper presents the author’s scientific hypothesis on the effect of fractal flickering, which exhibits scale invariance with time, on the evoked responses of the retina [electroretinogram (ERG)] and visual cortex [visual-evoked cortical potentials (VEP)] in norm and neurodegenerative disorders. A new approach for ERG and VEP studies is proposed. In the proposed approach, standard stimuli ar...